RapamycinFungusV1, Main, Exploration, bibRecord, 000A74

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.

Identifieur interne : 000A74 ( Main/Exploration ); précédent : 000A73; suivant : 000A75

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.

Source :

Molecular medicine reports [ 1791-3004 ] ; 2016.

RBID : pubmed:26717979

Descripteurs français

KwdFr :
- AMP-Activated Protein Kinases (métabolisme), Adénosine triphosphate (métabolisme), Animaux (MeSH), Fatigue (complications), Fatigue (enzymologie), Fatigue (traitement médicamenteux), Femelle (MeSH), Glutathione peroxidase (sang), Hypoxie (complications), Hypoxie (enzymologie), Hypoxie (traitement médicamenteux), Mâle (MeSH), Mélanges complexes (pharmacologie), Mélanges complexes (usage thérapeutique), Natation (MeSH), Phosphorylation (effets des médicaments et des substances chimiques), Rhodiola (composition chimique), Souris (MeSH), Superoxide dismutase (sang), Système nerveux autonome (effets des médicaments et des substances chimiques), Sérine-thréonine kinases TOR (métabolisme).
MESH :
- composition chimique : Fatigue, Hypoxie, Rhodiola.
- effets des médicaments et des substances chimiques : Phosphorylation, Système nerveux autonome.
- enzymologie : Fatigue, Hypoxie.
- métabolisme : AMP-Activated Protein Kinases, Adénosine triphosphate, Sérine-thréonine kinases TOR.
- pharmacologie : Mélanges complexes.
- sang : Glutathione peroxidase, Superoxide dismutase.
- traitement médicamenteux : Fatigue, Hypoxie.
- usage thérapeutique : Mélanges complexes.
- Animaux, Femelle, Mâle, Natation, Souris.

English descriptors

KwdEn :
- AMP-Activated Protein Kinases (metabolism), Adenosine Triphosphate (metabolism), Animals (MeSH), Autonomic Nervous System (drug effects), Complex Mixtures (pharmacology), Complex Mixtures (therapeutic use), Fatigue (complications), Fatigue (drug therapy), Fatigue (enzymology), Female (MeSH), Glutathione Peroxidase (blood), Hypoxia (complications), Hypoxia (drug therapy), Hypoxia (enzymology), Male (MeSH), Mice (MeSH), Phosphorylation (drug effects), Rhodiola (chemistry), Superoxide Dismutase (blood), Swimming (MeSH), TOR Serine-Threonine Kinases (metabolism).
MESH :
- chemical , blood : Glutathione Peroxidase, Superoxide Dismutase.
- chemical , metabolism : AMP-Activated Protein Kinases, Adenosine Triphosphate, TOR Serine-Threonine Kinases.
- chemistry : Rhodiola.
- complications : Fatigue, Hypoxia.
- drug effects : Autonomic Nervous System, Phosphorylation.
- drug therapy : Fatigue, Hypoxia.
- enzymology : Fatigue, Hypoxia.
- chemical , pharmacology : Complex Mixtures.
- chemical , therapeutic use : Complex Mixtures.
- Animals, Female, Male, Mice, Swimming.

Abstract

Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti‑inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant‑associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)‑5'‑monophosphate (AMP)‑activated protein kinase (AMPK), p‑protein kinase B (AKT) and p‑mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.

DOI: 10.3892/mmr.2015.4734
PubMed: 26717979

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000B28
to stream Main, to step Curation: 000B28

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.</title>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Lan Zhou" sort="Li, Lan Zhou" uniqKey="Li L" first="Lan Zhou" last="Li">Lan Zhou Li</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yan Ge" sort="Liu, Yan Ge" uniqKey="Liu Y" first="Yan Ge" last="Liu">Yan Ge Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teng, Li Rong" sort="Teng, Li Rong" uniqKey="Teng L" first="Li Rong" last="Teng">Li Rong Teng</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lu, Jia Hui" sort="Lu, Jia Hui" uniqKey="Lu J" first="Jia Hui" last="Lu">Jia Hui Lu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Wen Ji" sort="Hu, Wen Ji" uniqKey="Hu W" first="Wen Ji" last="Hu">Wen Ji Hu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118</wicri:regionArea>
<wicri:noRegion>Jilin 130118</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Di" sort="Wang, Di" uniqKey="Wang D" first="Di" last="Wang">Di Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teng, Le Sheng" sort="Teng, Le Sheng" uniqKey="Teng L" first="Le Sheng" last="Teng">Le Sheng Teng</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26717979</idno>
<idno type="pmid">26717979</idno>
<idno type="doi">10.3892/mmr.2015.4734</idno>
<idno type="wicri:Area/Main/Corpus">000B28</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B28</idno>
<idno type="wicri:Area/Main/Curation">000B28</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000B28</idno>
<idno type="wicri:Area/Main/Exploration">000B28</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.</title>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Lan Zhou" sort="Li, Lan Zhou" uniqKey="Li L" first="Lan Zhou" last="Li">Lan Zhou Li</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yan Ge" sort="Liu, Yan Ge" uniqKey="Liu Y" first="Yan Ge" last="Liu">Yan Ge Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teng, Li Rong" sort="Teng, Li Rong" uniqKey="Teng L" first="Li Rong" last="Teng">Li Rong Teng</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lu, Jia Hui" sort="Lu, Jia Hui" uniqKey="Lu J" first="Jia Hui" last="Lu">Jia Hui Lu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hu, Wen Ji" sort="Hu, Wen Ji" uniqKey="Hu W" first="Wen Ji" last="Hu">Wen Ji Hu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country>
<wicri:regionArea>Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118</wicri:regionArea>
<wicri:noRegion>Jilin 130118</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Di" sort="Wang, Di" uniqKey="Wang D" first="Di" last="Wang">Di Wang</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Teng, Le Sheng" sort="Teng, Le Sheng" uniqKey="Teng L" first="Le Sheng" last="Teng">Le Sheng Teng</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</nlm:affiliation>
<orgName type="university">Université de Jilin</orgName>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Molecular medicine reports</title>
<idno type="eISSN">1791-3004</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AMP-Activated Protein Kinases (metabolism)</term>
<term>Adenosine Triphosphate (metabolism)</term>
<term>Animals (MeSH)</term>
<term>Autonomic Nervous System (drug effects)</term>
<term>Complex Mixtures (pharmacology)</term>
<term>Complex Mixtures (therapeutic use)</term>
<term>Fatigue (complications)</term>
<term>Fatigue (drug therapy)</term>
<term>Fatigue (enzymology)</term>
<term>Female (MeSH)</term>
<term>Glutathione Peroxidase (blood)</term>
<term>Hypoxia (complications)</term>
<term>Hypoxia (drug therapy)</term>
<term>Hypoxia (enzymology)</term>
<term>Male (MeSH)</term>
<term>Mice (MeSH)</term>
<term>Phosphorylation (drug effects)</term>
<term>Rhodiola (chemistry)</term>
<term>Superoxide Dismutase (blood)</term>
<term>Swimming (MeSH)</term>
<term>TOR Serine-Threonine Kinases (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>AMP-Activated Protein Kinases (métabolisme)</term>
<term>Adénosine triphosphate (métabolisme)</term>
<term>Animaux (MeSH)</term>
<term>Fatigue (complications)</term>
<term>Fatigue (enzymologie)</term>
<term>Fatigue (traitement médicamenteux)</term>
<term>Femelle (MeSH)</term>
<term>Glutathione peroxidase (sang)</term>
<term>Hypoxie (complications)</term>
<term>Hypoxie (enzymologie)</term>
<term>Hypoxie (traitement médicamenteux)</term>
<term>Mâle (MeSH)</term>
<term>Mélanges complexes (pharmacologie)</term>
<term>Mélanges complexes (usage thérapeutique)</term>
<term>Natation (MeSH)</term>
<term>Phosphorylation (effets des médicaments et des substances chimiques)</term>
<term>Rhodiola (composition chimique)</term>
<term>Souris (MeSH)</term>
<term>Superoxide dismutase (sang)</term>
<term>Système nerveux autonome (effets des médicaments et des substances chimiques)</term>
<term>Sérine-thréonine kinases TOR (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Glutathione Peroxidase</term>
<term>Superoxide Dismutase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>AMP-Activated Protein Kinases</term>
<term>Adenosine Triphosphate</term>
<term>TOR Serine-Threonine Kinases</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Rhodiola</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Fatigue</term>
<term>Hypoxia</term>
</keywords>
<keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Fatigue</term>
<term>Hypoxie</term>
<term>Rhodiola</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autonomic Nervous System</term>
<term>Phosphorylation</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Fatigue</term>
<term>Hypoxia</term>
</keywords>
<keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Phosphorylation</term>
<term>Système nerveux autonome</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Fatigue</term>
<term>Hypoxie</term>
</keywords>
<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Fatigue</term>
<term>Hypoxia</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>AMP-Activated Protein Kinases</term>
<term>Adénosine triphosphate</term>
<term>Sérine-thréonine kinases TOR</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Mélanges complexes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Complex Mixtures</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Glutathione peroxidase</term>
<term>Superoxide dismutase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Complex Mixtures</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Fatigue</term>
<term>Hypoxie</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Mélanges complexes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Male</term>
<term>Mice</term>
<term>Swimming</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Femelle</term>
<term>Mâle</term>
<term>Natation</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti‑inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant‑associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)‑5'‑monophosphate (AMP)‑activated protein kinase (AMPK), p‑protein kinase B (AKT) and p‑mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26717979</PMID>
<DateCompleted><Year>2016</Year>
<Month>10</Month>
<Day>31</Day>
</DateCompleted>
<DateRevised><Year>2017</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1791-3004</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>13</Volume>
<Issue>2</Issue>
<PubDate><Year>2016</Year>
<Month>Feb</Month>
</PubDate>
</JournalIssue>
<Title>Molecular medicine reports</Title>
<ISOAbbreviation>Mol Med Rep</ISOAbbreviation>
</Journal>
<ArticleTitle>Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.</ArticleTitle>
<Pagination><MedlinePgn>1861-8</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3892/mmr.2015.4734</ELocationID>
<Abstract><AbstractText>Paecilomyces hepiali, one of the most valuable and effective Chinese medicinal herbs, possesses potential antioxidant, immunomodulatory, antitumor and anti‑inflammatory properties. The present study aimed to investigate the antifatigue and antihypoxic effects of Paecilomyces hepiali extract (PHC) in a mouse model. Using a rotating rod, forced swimming and running assessment, the antifatigue activity of PHC was determined. PHC administration for 7 days had no effect on mouse horizontal or vertical movement, indicating no neurotoxicity at the selected doses was observed. Using a normobaric hypoxia, sodium nitrite toxicosis and acute cerebral ischemia assessments, PHC was confirmed to possess antihypoxic effects. PHC treatment for 7 days significantly enhanced the serum and liver levels of adenosine triphosphate, superoxide dismutase and glutathione peroxidase, prior to and following 60 min of swimming. The levels of antioxidant‑associated proteins in the livers of the mice were analyzed using western blotting. PHC effectively increased the expression levels of phosphorylated (p)‑5'‑monophosphate (AMP)‑activated protein kinase (AMPK), p‑protein kinase B (AKT) and p‑mammalian target of rapamycin (mTOR). The results of the present study demonstrated that PHC efficiently enhanced endurance from fatigue and had antihypoxic effects through elevation of the antioxidant capacity in the serum and liver, at least in part through the AMPK and AKT/mTOR pathways. These results indicate the potential of this natural product as an antioxidant in the treatment of fatigue, hypoxia and their associated diseases.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Lan Zhou</ForeName>
<Initials>LZ</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yan Ge</ForeName>
<Initials>YG</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Teng</LastName>
<ForeName>Li Rong</ForeName>
<Initials>LR</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Lu</LastName>
<ForeName>Jia Hui</ForeName>
<Initials>JH</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Xie</LastName>
<ForeName>Jing</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Hu</LastName>
<ForeName>Wen Ji</ForeName>
<Initials>WJ</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yan</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Yang</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi, Jilin Agricultural University, Changchun, Jilin 130118, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Di</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Teng</LastName>
<ForeName>Le Sheng</ForeName>
<Initials>le S</Initials>
<AffiliationInfo><Affiliation>School of Life Sciences, Jilin University, Changchun, Jilin 130012, P.R. China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2015</Year>
<Month>12</Month>
<Day>30</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Greece</Country>
<MedlineTA>Mol Med Rep</MedlineTA>
<NlmUniqueID>101475259</NlmUniqueID>
<ISSNLinking>1791-2997</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D045424">Complex Mixtures</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>8L70Q75FXE</RegistryNumber>
<NameOfSubstance UI="D000255">Adenosine Triphosphate</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.11.1.9</RegistryNumber>
<NameOfSubstance UI="D005979">Glutathione Peroxidase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 1.15.1.1</RegistryNumber>
<NameOfSubstance UI="D013482">Superoxide Dismutase</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber>
<NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 2.7.11.31</RegistryNumber>
<NameOfSubstance UI="D055372">AMP-Activated Protein Kinases</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D055372" MajorTopicYN="N">AMP-Activated Protein Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000255" MajorTopicYN="N">Adenosine Triphosphate</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001341" MajorTopicYN="N">Autonomic Nervous System</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D045424" MajorTopicYN="N">Complex Mixtures</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005221" MajorTopicYN="N">Fatigue</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005979" MajorTopicYN="N">Glutathione Peroxidase</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000860" MajorTopicYN="N">Hypoxia</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D029771" MajorTopicYN="N">Rhodiola</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013482" MajorTopicYN="N">Superoxide Dismutase</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013550" MajorTopicYN="N">Swimming</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year>
<Month>02</Month>
<Day>06</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2015</Year>
<Month>12</Month>
<Day>02</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2016</Year>
<Month>11</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">26717979</ArticleId>
<ArticleId IdType="doi">10.3892/mmr.2015.4734</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Jilin</li>
</region>
<settlement><li>Changchun</li>
</settlement>
<orgName><li>Université de Jilin</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Jilin"><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
</region>
<name sortKey="Hu, Wen Ji" sort="Hu, Wen Ji" uniqKey="Hu W" first="Wen Ji" last="Hu">Wen Ji Hu</name>
<name sortKey="Li, Lan Zhou" sort="Li, Lan Zhou" uniqKey="Li L" first="Lan Zhou" last="Li">Lan Zhou Li</name>
<name sortKey="Liu, Yan" sort="Liu, Yan" uniqKey="Liu Y" first="Yan" last="Liu">Yan Liu</name>
<name sortKey="Liu, Yan Ge" sort="Liu, Yan Ge" uniqKey="Liu Y" first="Yan Ge" last="Liu">Yan Ge Liu</name>
<name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name>
<name sortKey="Lu, Jia Hui" sort="Lu, Jia Hui" uniqKey="Lu J" first="Jia Hui" last="Lu">Jia Hui Lu</name>
<name sortKey="Teng, Le Sheng" sort="Teng, Le Sheng" uniqKey="Teng L" first="Le Sheng" last="Teng">Le Sheng Teng</name>
<name sortKey="Teng, Li Rong" sort="Teng, Li Rong" uniqKey="Teng L" first="Li Rong" last="Teng">Li Rong Teng</name>
<name sortKey="Wang, Di" sort="Wang, Di" uniqKey="Wang D" first="Di" last="Wang">Di Wang</name>
<name sortKey="Xie, Jing" sort="Xie, Jing" uniqKey="Xie J" first="Jing" last="Xie">Jing Xie</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A74 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A74 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Bois
   |area=    RapamycinFungusV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26717979
   |texte=   Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26717979" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a RapamycinFungusV1

This area was generated with Dilib version V0.6.38.
Data generation: Thu Nov 19 21:55:41 2020. Site generation: Thu Nov 19 22:00:39 2020

	Serveur d'exploration sur la rapamycine et les champignons
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la rapamycine et les champignons

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.

Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki